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+macOS
+=====
+
+It is recommended to use Homebrew to install the dependencies for Boxes.py.
+See `brew.sh <https://brew.sh>`__ on how to install Homebrew.
+
+General
+-------
+
+1. Install Python 3 and other dependencies:
+
+   .. code::
+
+      brew install python3 git
+
+   Optional:
+
+   .. code::
+
+      brew install pstoedit
+
+
+2. Install required Python modules:
+
+   .. code::
+
+      pip3 install pycairo cairocffi Markdown lxml
+
+3. Download Boxes.py via Git:
+
+   .. code::
+
+      git clone https://github.com/florianfesti/boxes.git
+
+4. Run Boxes.py:
+
+   Local web server on port 8000:
+
+   .. code::
+
+      ./scripts/boxesserver
+
+   Command line variant (CLI):
+
+   .. code::
+
+      ./scripts/boxes
+
+
+System-wide with Inkscape extension
+-----------------------------------
+
+To install Boxes.py system-wide with the Inkscape extension, following steps
+are required:
+
+1. Install Inkscape with Homebrew Cask
+   (requires `XQuartz <https://www.xquartz.org/>`__):
+
+   .. code::
+
+      brew cask install inkscape
+
+2. From the root directory of the repository, run:
+
+   .. code::
+
+      ./setup.py install
+
+3. Now :code:`boxes` and :code:`boxesserver` can be runned like other commands
+   and the Inkscape extension should be available.